Brederick's reagent

COc1nc(C(=O)C(F)=CN(C)C)c(NC(=O)OC(C)(C)C)cc1F

Reaction #43410

Ausbeute 49.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

COc1cc(C(C)C)c(OC(C#N)C(N(C)C)N(C)C)cc1I

Reaction #46950

3,3-bis-dimethylamino-2-(5-iodo-2-isopropyl-4-methoxy-phenoxy)-propionitrile

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_06

CN(C)C=C(C(=O)c1c[nH]c(C(=O)NCc2ccccc2)c1)c1ccccc1

Reaction #50898

4-(3-Dimethylamino-2-phenyl-acryloyl)-1H-pyrrole-2-carboxylic acid benzylamide

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2005_02

Cc1ccc2[nH]ccc2c1Br

Reaction #53551

4-bromo-5-methylindole

Ausbeute 29.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2005_02

COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1[N+](=O)[O-]

Reaction #66643

5-(2-isopropyl-4-methoxy-5-nitro-phenoxy)-pyrimidine-2,4-diamine

Ausbeute 71.8%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_09

COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1-c1cscn1

Reaction #66678

5-(2-Isopropyl-4-methoxy-5-thiazol-4-yl-phenoxy)-pyrimidine-2,4-diamine

Ausbeute 68.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_09

CN(C)C=C(C(=O)c1c[nH]c(C(=O)NCc2ccccc2)c1)c1ccccc1

Reaction #75537

4-(3-Dimethylamino-2-phenyl-acryloyl)-1H-pyrrole-2-carboxylic acid benzylamide

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2004_03

COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1[N+](=O)[O-]

Reaction #168964

5-(2-isopropyl-4-methoxy-5-nitro-phenoxy)-pyrimidine-2,4-diamine

Ausbeute 71.8%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09

COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1-c1cscn1

Reaction #168997

5-(2-Isopropyl-4-methoxy-5-thiazol-4-yl-phenoxy)-pyrimidine-2,4-diamine

Ausbeute 68.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09

COc1ccc2nc(Cl)cc(C=CN(C)C)c2c1

Reaction #182120

DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (2/10)

CN(C)C=Cc1ccc([N+](=O)[O-])cc1Cl

Reaction #198278

DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (2/10)

$CN(C)/C=C1\CC(NC(=O)OC(C)(C)C)(c2cccc(C(C)(C)C)c2)CCC1=O$

Reaction #219295

(E)-tert-butyl 1-(3-tert-butylphenyl)-3-((dimethylamino)methylene)-4-oxocyclohexylcarbamate

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2008_06

OC[C@H]1N[C@@H](c2cnc3c(O)nc[nH]c2-3)C[C@@H]1O

Reaction #220666

(1S)-N-tert-butoxycarbonyl-5-O-tert-butyldimethylsilyl-1-C-(1-cyano-2-hydroxyethenyl)-1,4-dideoxy-1,4-imino-2,3-O-isopropylidene-D-ribitol

Ausbeute 86.8%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2008_06

CCOP(=O)(NC1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=C(C=CN(C)C)CSC12)OCC

Reaction #224753

DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (9/10)

CN(C)C=CC(=O)c1ccc(C(=O)N2Cc3ccnn3Cc3ccccc32)cc1

Reaction #228537

DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (9/10)

CN(C)C=C1CCc2cc(Oc3ccc(F)cc3F)c([N+](=O)[O-])cc21

Reaction #228773

DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (9/10)

CN(C)C=C1CCCCC(c2cc(Cl)ccc2Cl)C1=O

Reaction #261530

DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (9/10)

COc1ccc(C(=O)/C=C/N(C)C)cc1COC(=O)C(C)(C)C

Reaction #305528

5-[(2E)-3-(dimethylamino)prop-2-enoyl]-2-methoxybenzyl pivalate

Ausbeute 79.6%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_06

Cc1cc(Br)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(/C=C/N(C)C)c1[N+](=O)[O-]

Reaction #309248

desired product

Ausbeute 92.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_06

Cc1cc(Br)cc(C)c1Nc1nc(Nc2ccc(C#N)cc2)nc(/C=C/N(C)C)c1[N+](=O)[O-]

Reaction #309253

(E)-4-(4-(4-bromo-2,6-dimethylphenylamino)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidin-2-ylamino)benzonitrile

Ausbeute 67.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_06

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