Reaktion #50898

ord-3c9b471365bf49f697c09710436f04f8

Reaktionsgleichung

O=C(Cc1ccccc1)c1c[nH]c(C(=O)NCc2ccccc2)c1
compound 2
O=C(Cc1ccccc1)c1c[nH]c(C(=O)NCc2ccccc2)c1
4-Phenylacetyl-1H-pyrrole-2-carboxylic acid benzylamide
CN(C)C(OC(C)(C)C)N(C)C
(Me2N)2CHOt-Bu
→
CN(C)C=C(C(=O)c1c[nH]c(C(=O)NCc2ccccc2)c1)c1ccccc1
4-(3-Dimethylamino-2-phenyl-acryloyl)-1H-pyrrole-2-carboxylic acid benzylamide

Edukte

O=C(Cc1ccccc1)c1c[nH]c(C(=O)NCc2ccccc2)c1
compound 2
O=C(Cc1ccccc1)c1c[nH]c(C(=O)NCc2ccccc2)c1
4-Phenylacetyl-1H-pyrrole-2-carboxylic acid benzylamide
CN(C)C(OC(C)(C)C)N(C)C
(Me2N)2CHOt-Bu

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigethe solvent was evaporated
  2. 2
    Sonstigethe crude product 3 was utilized without purification

Vorschrift

To a solution of compound 2 (1 equivalent) in THF, at ambient temperature, was added (Me2N)2CHOt-Bu (3 equivalents). After 24 hours, the solvent was evaporated and the crude product 3 was utilized without purification. 1H NMR (CDCl3) □4.4 (s, 2H), 4.8 (s, NH), 6.8-7.4 (m, 13H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06849267B2uspto-grants-2005_02