Reaktion #219295

ord-c031964a759547a3b6ff31357bdf101f

Reaktionsgleichung

CC(C)(C)OC(=O)NC1(c2cccc(C(C)(C)C)c2)CCC(=O)CC1
tert-butyl 1-(3-tert-butylphenyl)-4-oxocyclohexylcarbamate
CN(C)C(OC(C)(C)C)N(C)C
tert-butoxybis(dimethylamino)methane
→
CN(C)/C=C1\CC(NC(=O)OC(C)(C)C)(c2cccc(C(C)(C)C)c2)CCC1=O
(E)-tert-butyl 1-(3-tert-butylphenyl)-3-((dimethylamino)methylene)-4-oxocyclohexylcarbamate

Edukte

CC(C)(C)OC(=O)NC1(c2cccc(C(C)(C)C)c2)CCC(=O)CC1
tert-butyl 1-(3-tert-butylphenyl)-4-oxocyclohexylcarbamate
CN(C)C(OC(C)(C)C)N(C)C
tert-butoxybis(dimethylamino)methane

Reagenzien

Keine

Lösungsmittel

Cc1ccccc1
Toluene

Reaktionsbedingungen

Temperatur
85°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    EinengenThe reaction was concentrated

Vorschrift

To a stirred solution of tert-butyl 1-(3-tert-butylphenyl)-4-oxocyclohexylcarbamate (691 mg, 2.0 mmol) in Toluene (5 mL) was added tert-butoxybis(dimethylamino)methane (454 μL, 2.2 mmol). The reaction was stirred at 85° C. overnight. The reaction was concentrated and used crude in the next step.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07385085B2uspto-grants-2008_06