3′-{N′-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid

$CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O.NCCO$

Reaction #87892

Eltrombopag Olamine

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2016_09

$CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O.NCCO$

Reaction #87899

Eltrombopag Olamine

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2016_09

$CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)O)c2)c1O.NCCO$

Reaction #87900

Eltrombopag Olamine

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2016_09

$COC(=O)c1cccc(-c2cccc(N/N=C3\C(=O)N(c4ccc(C)c(C)c4)N=C3C)c2O)c1$

Reaction #473554

(Z)-methyl 3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carboxylate

Ausbeute 83.3%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_02

$CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)Cl)c2)c1O$

Reaction #473555

(Z)-3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carbonyl chloride

Ausbeute 96.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_02

$COC(=O)c1cccc(-c2cccc(N/N=C3\C(=O)N(c4ccc(C)c(C)c4)N=C3C)c2O)c1$

Reaction #997520

(Z)-methyl 3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carboxylate

Ausbeute 83.3%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2011_09

$CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)Cl)c2)c1O$

Reaction #997521

(Z)-3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carbonyl chloride

Ausbeute 96.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2011_09

CC1=NN(c2ccc(C)c(C)c2)C(=O)C1=NNc1cccc(-c2cccc(C(=O)Cl)c2)c1O

Reaction #1303160

DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (5/10)

$COC(=O)c1cccc(-c2cccc(N/N=C3\C(=O)N(c4ccc(C)c(C)c4)N=C3C)c2O)c1$

Reaction #1598711

(Z)-methyl 3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carboxylate

Ausbeute 83.3%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_07

$CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)Cl)c2)c1O$

Reaction #1598712

(Z)-3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carbonyl chloride

Ausbeute 96.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_07

$COC(=O)c1cccc(-c2cccc(N/N=C3\C(=O)N(c4ccc(C)c(C)c4)N=C3C)c2O)c1$

Reaction #2507856

(Z)-methyl 3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carboxy late

Ausbeute 83.3%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2011_06

$CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=N\Nc1cccc(-c2cccc(C(=O)Cl)c2)c1O$

Reaction #2507857

(Z)-3′-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carbonyl chloride

Ausbeute 96.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2011_06