Reaktion #87899

Reaktionsgleichung

3′-{N′-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid

ethanolamine

→

Eltrombopag Olamine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturheated
3. 3
   Temperaturto about reflux temperature for about 2 hours
4. 4
   TemperaturThe mixture was cooled to about 0° C. to about 10° C.
5. 5
   FiltrationThe reaction mixture was filtered
6. 6
   Waschenwashed with water (10 mL)
7. 7
   Sonstigedried in an oven at about 55° C. to about 60° C. for about 12 hours
8. 8
   Sonstigeto get purple solid

Vorschrift

To a mixture of 3′-{N′-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid (2 g) in water (40 mL), ethanolamine (2.5 g) was added and heated to about reflux temperature for about 2 hours. The mixture was cooled to about 0° C. to about 10° C. and stirred for about 1 hour. The reaction mixture was filtered, washed with water (10 mL) and dried in an oven at about 55° C. to about 60° C. for about 12 hours to get purple solid.

Quelle