Reaktion #87900

Reaktionsgleichung

3′-{N′-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid

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Eltrombopag Olamine

Lösungsmittel

ethanolamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated at about 55° C. to about 60° C. for 2 hours
2. 2
   TemperaturThe mixture was cooled to about room temperature
3. 3
   FiltrationIt was filtered
4. 4
   Waschenwashed with ethanol (10 mL)
5. 5
   Sonstigedried in an oven at about 55° C. to about 60° C. for about 12 hours
6. 6
   Sonstigeto get purple solid

Vorschrift

A mixture of 3′-{N′-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid (2 g) and ethanolamine (10 mL) was heated at about 55° C. to about 60° C. for 2 hours. The mixture was cooled to about room temperature and stirred for about 1 hour. It was filtered, washed with ethanol (10 mL) and dried in an oven at about 55° C. to about 60° C. for about 12 hours to get purple solid. Yield: 1.7 g; Melting point: 237.3-237.6° C.

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