Reaction #1985

title compound

収率 99.9%DOI: 10.6084/m9.figshare.5104873.v1

Cc1ccccc1S(=O)(=O)OCC1(C(F)(F)F)CCN(Cc2ccccc2)C1

Reaction #1986

title compound

DOI: 10.6084/m9.figshare.5104873.v1

Cc1nc(C)c(-c2cn(CCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)c(=O)[nH]c2=O)o1.Cl

Reaction #41069

title compound

DOI: 10.6084/m9.figshare.5104873.v1

Cc1nc(C)c(-c2cn(CCCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)c(=O)[nH]c2=O)o1.Cl

Reaction #41070

title compound

収率 24.0%DOI: 10.6084/m9.figshare.5104873.v1

OC(CCCC(F)(F)F)(Cc1ccccc1-c1ccccc1)C1CN(Cc2ccccc2)CCO1

Reaction #58608

67

収率 28.0%DOI: 10.6084/m9.figshare.5104873.v1

O=C(c1cc(-n2cnnn2)ccc1N1CCOCC1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1

Reaction #60974

title compound

収率 52.0%DOI: 10.6084/m9.figshare.5104873.v1

COc1ccc(CS[C@H]2C[C@@H](C(=O)N3CCCN(CCOC(=O)OCc4ccc([N+](=O)[O-])cc4)CC3)N(C(=O)OCc3ccc([N+](=O)[O-])cc3)C2)cc1

Reaction #65625

title compound

収率 62.1%DOI: 10.6084/m9.figshare.5104873.v1

COC1(c2cc(F)cc(Sc3ccc4c(c3)CCC(=O)N4C)c2)CCN(CC(F)F)C1

Reaction #65827

3-[5-fluoro-3-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-1-(2,2-difluoroethyl)-3-methoxypyrrolidine

収率 51.0%DOI: 10.6084/m9.figshare.5104873.v1

COC(=O)NC(CCC(F)(F)F)C(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CCCN5)[nH]4)cc3)cc2)[nH]1

Reaction #159201

pyrrolidine

収率 92.3%DOI: 10.6084/m9.figshare.5104873.v1

COC(=O)NC(CCC(F)(F)F)C(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CCCN5C(=O)C(NC(=O)OC)C(C)C)[nH]4)cc3)cc2)[nH]1

Reaction #159202

(4,4,4-trifluoro-1-{2-[5-(4′-{2-[1-(2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-butyl)-carbamic acid methyl ester

収率 47.0%DOI: 10.6084/m9.figshare.5104873.v1

COC(=O)NC(CCC(F)(F)F)C(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CCCN5C(=O)C(CCC(F)(F)F)NC(=O)OC)[nH]4)cc3)cc2)[nH]1

Reaction #159203

(4,4,4-Trifluoro-1-{2-[5-(4′-{2-[1-(5,5,5-trifluoro-2-methoxycarbonylamino-pentanoyl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-butyl)-carbamic acid methyl ester

収率 23.0%DOI: 10.6084/m9.figshare.5104873.v1

COC(=O)NC(CCOCC(F)(F)F)C(=O)N1CCCC1c1ncc(-c2ccc(-c3ccc(-c4cnc(C5CCCN5)[nH]4)cc3)cc2)[nH]1

Reaction #159207

[1-(2-{5-[4′-(2-Pyrrolidin-2-yl-3H-imidazol-4-yl)-biphenyl-4-yl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-3-(2,2,2-trifluoroethoxy)-propyl]-carbamic acid methyl ester

DOI: 10.6084/m9.figshare.5104873.v1

Reaction #161710

6-chloropyrimidine-4-carboxylic acid-benzyl-(2,2,2-trifluoro-ethyl)-amide

DOI: 10.6084/m9.figshare.5104873.v1

COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)N(Cc4ccccc4)CC(F)(F)F)ncn3)CC1)C(=O)N2

Reaction #161806

6-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid benzyl-(2,2,2-trifluorethyl)-amide

DOI: 10.6084/m9.figshare.5104873.v1

Reaction #167143

pyrrolidine

収率 92.3%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #167144

(4,4,4-trifluoro-1-{2-[5-(4′-{2-[1-(2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-butyl)-carbamic acid methyl ester

収率 47.0%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #167145

(4,4,4-Trifluoro-1-{2-[5-(4′-{2-[1-(5,5,5-trifluoro-2-methoxycarbonylamino-pentanoyl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-butyl)-carbamic acid methyl ester

収率 23.0%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #167149

[1-(2-{5-[4′-(2-Pyrrolidin-2-yl-3H-imidazol-4-yl)-biphenyl-4-yl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-3-(2,2,2-trifluoroethoxy)-propyl]-carbamic acid methyl ester

DOI: 10.6084/m9.figshare.5104873.v1

C=C(C)[C@@H]1CC[C@]2(NCCCN3CCCC3=O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)OC)c(F)c6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12

Reaction #172878

methyl 2-fluoro-4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11a-pentamethyl-3a-(3-(2-oxopyrrolidin-1-yl)propylamino)-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate

収率 26.2%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #173000

DOI: 10.1039/C8SC04228D

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