反応 #65827

反応方程式

6-mercapto-1-methyl-1,2,3,4-tetrahydroquinolin-2-one

1-(2,2-difluoroethyl)-3-(3,5-difluorophenyl)-3-methoxypyrrolidine hydrochloride

→

3-[5-fluoro-3-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-1-(2,2-difluoroethyl)-3-methoxypyrrolidine

収率 51.0%

反応条件

実験手順

Using an analogous procedure to that described in Example 6, 6-mercapto-1-methyl-1,2,3,4-tetrahydroquinolin-2-one was reacted with 1-(2,2-difluoroethyl)-3-(3,5-difluorophenyl)-3-methoxypyrrolidine hydrochloride to give 3-[5-fluoro-3-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-ylthio)phenyl]-1-(2,2-difluoroethyl)-3-methoxypyrrolidine as a gum in 51% yield.

出典