反応 #1986

反応方程式

compound

1-benzyl-3-trifluoromethylpyrrolidine-3-methanol

pyridine

p-toluenesulfonyl chloride

pyridine

→

title compound

1-benzyl-3-trifluoromethyl-3-(toluenesulfonyloxymethyl)pyrrolidine

溶媒

methylene chloride

反応条件

後処理

1. 1
   洗浄washed with water and brine
2. 2
   その他dried
3. 3
   その他Removal of the solvent

実験手順

The compound from step 456b (1.61 g) was dissolved in dry pyridine, and the solution was cooled to 0° C. To this was added 1.458 g of p-toluenesulfonyl chloride in 4 mL of dry pyridine, and the reaction was stirred at 0.C for 4 days. The mixture was diluted with 300 mL of methylene chloride, then washed with water and brine and dried. Removal of the solvent gave 2.81 g of the title compound.

出典