بحث البنية الفرعية

NCCCN1CCCC1

O=C1CCCN1CCCNc1c([N+](=O)[O-])cnc2cc(Br)ccc12

1-[3-(7-bromo-3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one

المردود 84.0%DOI: 10.6084/m9.figshare.5104873.v1

O=C1CCCN1CCCNc1c([N+](=O)[O-])cnc2ccc(Br)cc12

1-[3-(6-bromo-3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one

المردود 87.8%DOI: 10.6084/m9.figshare.5104873.v1

O=C1CCCN1CCCNc1c([N+](=O)[O-])cnc2cc(-c3ccccc3)ccc12

1-[3-(3-nitro-7-phenylquinolin-4-ylamino)propyl]pyrrolidin-2-one

المردود 88.1%DOI: 10.6084/m9.figshare.5104873.v1

CCOC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(NCCCN3CCCC3=O)ncc2c1=O

Reaction #40618

8-Indan-5-yl-5-oxo-2-[3-(2-oxo-pyrrolidin-1-yl)-propylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

DOI: 10.6084/m9.figshare.5104873.v1

CCOC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(NCCCN3CCCC3)ncc2c1=O

Reaction #40619

8-Indan-5-yl-5-oxo-2-(3-pyrrolidin-1-yl-propylamino)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

DOI: 10.6084/m9.figshare.5104873.v1

Reaction #40636

المردود 85.0%DOI: 10.6084/m9.figshare.5104873.v1

COc1c2c(c3n(c1=O)CCC(N1CCCC1)CN(C)C3=O)CCN(Cc1ccc(F)c(Cl)c1)C2=O

Reaction #46303

DOI: 10.6084/m9.figshare.5104873.v1

CN1CC(=O)CCn2c(c3c(c(O)c2=O)C(=O)N(Cc2ccc(F)c(Cl)c2)CC3)C1=O

Reaction #46304

DOI: 10.6084/m9.figshare.5104873.v1

CCNC(=O)NCCCN1CCCC1

Reaction #51336

المردود 96.4%DOI: 10.6084/m9.figshare.5104873.v1

CC1=C(C(=O)NCCCN2CCCC2)C(c2cccc(Cl)c2)NC(=O)N1

Reaction #52883

DOI: 10.6084/m9.figshare.5104873.v1

COC(=O)c1cc2c(ncn2CCC(=O)N2CCCC2)c(F)c1Nc1ccc(Br)cc1Cl

Reaction #60274

desired product

المردود 67.0%DOI: 10.6084/m9.figshare.5104873.v1

O=C(O)c1cc2c(ncn2CCC(=O)N2CCCC2)c(F)c1Nc1ccc(Br)cc1Cl

Reaction #60275

المردود 104.3%DOI: 10.6084/m9.figshare.5104873.v1

O=C(NCCCN1CCCC1=O)c1ccncc1Nc1ccc(I)cc1F

Reaction #67814

3-[(2-fluoro-4-iodophenyl)amino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]isonicotinamide

DOI: 10.6084/m9.figshare.5104873.v1

O=C(NCCCN1CCCC1=O)[C@@H]1CCCN1C(=O)OCc1ccccc1

Reaction #93118

(S)-1-benzyloxycarbonyl-N-[3-(2-oxo-pyrrolidinyl)propyl]-2-pyrrolidine carboxamide

المردود 29.7%DOI: 10.6084/m9.figshare.5104873.v1

CCC(COc1ccc2c(=O)n(-c3ccc(N4CC[C@@H](N5CCCC5)C4)c(F)c3)ccc2c1)OC

Reaction #156635

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-(2-methoxy-butoxy)-2H-isoquinolin-1-one

DOI: 10.6084/m9.figshare.5104873.v1

$CCC/C=C\c1ccc2c(=O)n(-c3ccc(N4CC[C@@H](N5CCCC5)C4)c(F)c3)ccc2c1$

Reaction #156641

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-((Z)-pent-1-enyl)-2H-isoquinolin-1-one

DOI: 10.6084/m9.figshare.5104873.v1

CCC[C@H](O)[C@H](O)c1ccc2c(=O)n(-c3ccc(N4CC[C@@H](N5CCCC5)C4)c(F)c3)ccc2c1

Reaction #156642

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-((1R*,2S*)-1,2-dihydroxy-pentyl)-2H-isoquinolin-1-one

DOI: 10.6084/m9.figshare.5104873.v1

CC(CC(C)(C)O)Oc1ccc2c(=O)n(-c3ccc(N4CC[C@@H](N5CCCC5)C4)c(F)c3)ccc2c1

Reaction #156706

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluoro-phenyl)-6-(3-hydroxy-1,3-dimethyl-butoxy)-2H-isoquinolin-1-one

DOI: 10.6084/m9.figshare.5104873.v1

O=c1c2ccc(OCC3OCCO3)cc2ccn1-c1ccc(N2CC[C@@H](N3CCCC3)C2)c(F)c1

Reaction #156707

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluoro-phenyl)-6-([1,3]dioxolan-2-ylmethoxy)-2H-isoquinolin-1-one

DOI: 10.6084/m9.figshare.5104873.v1

O=C(NCCCN1CCCC1)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1

Reaction #164327

(R/S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)-N-(3-(pyrrolidin-1-yl)propyl)acetamide

المردود 54.3%DOI: 10.6084/m9.figshare.5104873.v1

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