تفاعل #156641

معادلة التفاعل

2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-pent-1-ynyl-2H-isoquinolin-1-one

quinoline

→

2-((R)-4-[1,3′]Bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-((Z)-pent-1-enyl)-2H-isoquinolin-1-one

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   تركيزthe filtrate was concentrated
2. 2
   أخرىThe residue was purified by chromatography on silica gel
3. 3
   أخرىIn this way the product was obtained with molecular weight 445.59 (C28H32FN3O)

الإجراء التجريبي

A mixture of 2-((R)-4-[1,3′]bipyrrolidinyl-1′-yl-3-fluorophenyl)-6-pent-1-ynyl-2H-isoquinolin-1-one (2.7 g), quinoline (0.4 g), pyridine (50 mL) and palladium (5% on barium carbonate; 100 mg) was stirred vigorously for 2 hours under a hydrogen atmosphere (balloon flask). It was sucked off of the catalyst and the filtrate was concentrated. The residue was purified by chromatography on silica gel. In this way the product was obtained with molecular weight 445.59 (C28H32FN3O); MS (ESI): 446 (M+H+).

المصدر