تفاعل #51336

معادلة التفاعل

ethyl isocyanate

3-(1-pyrrolidinyl)propylamine

→

urea

المردود 96.4%

N-ethyl-N′-3-(1-pyrrolidinyl)propylurea

المردود 96.4%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwith cooling
2. 2
   workup.ADDITIONOnce the addition
3. 3
   أخرىthe cooling bath was removed
4. 4
   تركيزThe reaction mixture was then concentrated under reduced pressure

الإجراء التجريبي

To a solution of 27.7 g (0.39 mol) ethyl isocyanate in 250 mL chloroform was added 50 g (0.39 mol) 3-(1-pyrrolidinyl)propylamine dropwise with cooling. Once the addition was complete, the cooling bath was removed and the reaction mixture stirred at room temperature for 4 hours. The reaction mixture was then concentrated under reduced pressure to give 74.5 g (96.4%) of the desired urea as a clear oil.

المصدر