子结构搜索

3409

COc1ccccc1N(CCN1CCC(C(=O)c2ccc(F)cc2)CC1)C(=O)c1ccc(NC(=O)NC(C)(C)C)cc1

收率 77.6%DOI: 10.6084/m9.figshare.5104873.v1

O=C(NCC1CCC(CN(Cc2ccccc2)S(=O)(=O)NC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1)Nc1ccccc1

Reaction #52018

DOI: 10.6084/m9.figshare.5104873.v1

O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(-c2n[nH]cc2-c2ccncc2)c1

Reaction #74092

desired product

收率 75.0%DOI: 10.6084/m9.figshare.5104873.v1

O=C(Nc1ccc(C(F)(F)F)cc1)Nc1cccc(-c2nn(CCO)cc2-c2ccncc2)c1

Reaction #74095

1-{3-[1-(2-Hydroxy-ethyl)-4-pyridin-4-yl-1H-pyrazol-3-yl]-phenyl}-3-(4-trifluoromethyl-phenyl)-urea

DOI: 10.6084/m9.figshare.5104873.v1

CCOC(=O)n1cc(-c2ccncc2)c(-c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)n1

Reaction #74099

4-pyridin-4-yl-3-{3-[3-(4-trifluoromethyl-phenyl)-ureido]-phenyl}-pyrazole-1-carboxylic acid ethyl ester

收率 77.0%DOI: 10.6084/m9.figshare.5104873.v1

Nc1nccc(-c2c[nH]nc2-c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)n1

Reaction #74156

收率 73.2%DOI: 10.6084/m9.figshare.5104873.v1

CCc1ccc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1

Reaction #91769

1-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-3-(4-ethyl-phenyl)-urea

收率 64.4%DOI: 10.6084/m9.figshare.5104873.v1

Cc1cc(Cl)ccc1NC(=O)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O

Reaction #91770

1-(4-chloro-2-methyl-phenyl)-3-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-urea

收率 90.0%DOI: 10.6084/m9.figshare.5104873.v1

O=C1CCC(N2Cc3cc(CNC(=O)Nc4ccc(Cl)c(Cl)c4)ccc3C2=O)C(=O)N1

Reaction #91772

1-(3,4-dichloro-phenyl)-3-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-urea

收率 93.2%DOI: 10.6084/m9.figshare.5104873.v1

CCOc1ccc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1

Reaction #91780

1-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-3-(4-ethoxy-phenyl)-urea

收率 108.0%DOI: 10.6084/m9.figshare.5104873.v1

O=C1CCC(N2Cc3cc(CNC(=O)Nc4ccc(OC(F)(F)F)cc4)ccc3C2=O)C(=O)N1

Reaction #91781

1-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-3-(4-trifluoromethoxy-phenyl)-urea

收率 67.0%DOI: 10.6084/m9.figshare.5104873.v1

COc1ccc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1

Reaction #91783

1-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-3-(4-methoxy-phenyl)-urea

收率 84.0%DOI: 10.6084/m9.figshare.5104873.v1

N#Cc1ccc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1

Reaction #91789

1-(4-cyano-phenyl)-3-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-urea

收率 38.3%DOI: 10.6084/m9.figshare.5104873.v1

O=C1CCC(N2Cc3cc(CNC(=O)Nc4ccc(Cl)cc4Cl)ccc3C2=O)C(=O)N1

Reaction #91790

1-(2,4-dichloro-phenyl)-3-[2-(2,6-dioxo-piperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-ylmethyl]-urea

收率 96.0%DOI: 10.6084/m9.figshare.5104873.v1

$C/C(=N\OCCN)c1cccc(C(C)(C)NC(=O)Nc2ccc(Cl)c([N+](=O)[O-])c2)c1$

Reaction #92501

收率 46.0%DOI: 10.6084/m9.figshare.5104873.v1

O=C(O)c1cccc(N2CCC(N3CCc4ccccc4NC3=O)CC2)c1

Reaction #161683

3-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-benzoic acid

DOI: 10.6084/m9.figshare.5104873.v1

CC1(C)CN(C(=O)c2cccc(N3CCC(N4CCc5ccccc5NC4=O)CC3)c2)Cc2cn[nH]c21

Reaction #161801

3-{1-[3-(7,7-dimethyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-carbonyl)-phenyl]-piperidin-4-yl}-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

DOI: 10.6084/m9.figshare.5104873.v1

NC(=O)N(C1=CCC(Cl)(C(=O)Nc2cccc(C(=O)Nc3cccnc3)c2)C=C1)c1ccccc1C(F)(F)F

Reaction #165518

4-chloro-3-((trifluoromethyl)phenyl)-N′-(4-(N-(3-(N-(3-pyridyl)carbamoyl)phenyl)carbamoyl)phenyl)urea

收率 59.0%DOI: 10.6084/m9.figshare.5104873.v1

COC(=O)C(CC(=O)N1CCC(N2Cc3cc(O)ccc3NC2=O)CC1)Cc1cc(Cl)c(N)c(C(F)(F)F)c1

Reaction #173009

DOI: 10.1039/C8SC04228D

COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(Cl)c3)ccnc2cc1OCCN(C)CCO

Reaction #177766

DOI: 10.1039/C8SC04228D

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