#1236041

Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(N4CCC(N5CCCC5)CC4)c([N+](=O)[O-])cc23)cc1Cl
Reaction #174760
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
Cn1ccnc1Sc1ccc(I)cc1Cl
Reaction #187107
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3ccc([N+](=O)[O-])cc23)cc1Cl
Reaction #212345
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
Nc1ccc(O)cc1F
Reaction #250441
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
CCOc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1F
Reaction #262010
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1F
Reaction #356936
4-[3-chloro-4-(1-methyl-1H-imidazole-2-ylsulfanyl)-phenylamino]-7-fluoro-6-methoxyquinoline-3-carbonitrile
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2008_11
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(F)ccc23)cc1Cl
Reaction #356940
4-({3-chloro-4-[(1-methyl-1H-imidazole-2-yl)thio]phenyl}amino)-7-fluoroquinoline-3-carbonitrile
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2008_11
CCOc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1F
Reaction #356941
4-({3-chloro-4-[(1-methyl-1H-imidazole-2-yl)sulfanyl]phenyl}amino)-6-ethoxy-7-fluoro-3-quinolinecarbonitrile
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2008_11
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1OCCCCl
Reaction #356943
4-{3-chloro-4-[(1-methyl-1H-imidazole-2-yl)sulfanyl]anilino}-7-(3-chloropropoxy)-6-methoxy-3-quinolinecarbonitrile
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2008_11
Cl.c1ccncc1
Reaction #356944
pyridine hydrochloride
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2008_11
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(N4CCC(N5CCCC5)CC4)c([N+](=O)[O-])cc23)cc1Cl
Reaction #356958
4-({3-chloro-4-[(1-methyl-1H-imidazole-2-yl)thio]phenyl}amino)-6-nitro-7-(4-pyrrolidin-1-ylpiperidin-1-yl)quinoline-3-carbonitrile
Выход 60.9%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2008_11
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(Br)ccc23)cc1Cl
Reaction #381663
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (8/10)
COc1cc2ncc(C#N)c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c2cc1OC
Reaction #395161
DOI: 10.1039/C8SC04228DTraining data from https://doi.org/10.1039/C8SC04228D (8/10)
COc1cc2ncnc(Nc3ccc(Sc4nccn4C)c(Cl)c3)c2cc1OC.Cl.Cl
Reaction #486643
4-[3-chloro-4-(1-methylimidazol-2-ylthio)anilino]-6,7-dimethoxyquinazoline dihydrochloride salt
Выход 71.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-1998_10
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1F
Reaction #586286
4-[3-chloro-4-(1-methyl-1H-imidazole-2-ylsulfanyl)-phenylamino]-7-fluoro-6-methoxyquinoline-3-carbonitrile
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_08
Cn1ccnc1Sc1ccc(Nc2c(C#N)cnc3cc(F)ccc23)cc1Cl
Reaction #586290
4-({3-chloro-4-[(1-methyl-1H-imidazole-2-yl)thio]phenyl}amino)-7-fluoroquinoline-3-carbonitrile
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_08
CCOc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1F
Reaction #586291
4-({3-chloro-4-[(1-methyl-1H-imidazole-2-yl)sulfanyl]phenyl}amino)-6-ethoxy-7-fluoro-3-quinolinecarbonitrile
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_08
COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(C#N)cnc2cc1OCCCl
Reaction #586293
7-(2-chloroethoxy)-4-{3-chloro-4-[(1-methyl-1H-imidazole-2-yl)sulfanyl]anilino}-6-methoxy-3-quinolinecarbonitrile
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_08
N#Cc1cc2ccccc2nc1N1CCC(N2CCCC2)CC1
Reaction #586305
4-pyrrolidin-1-ylpiperidin-1-ylquinoline-3-carbonitrile
DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2010_08
—
Reaction #657788
solid
Выход 10.4%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2015_05
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