Реакция #486643

Уравнение реакции

4-amino-2-chlorophenyl 1-methylimidazol-2-yl sulphide

4-chloro-6,7-dimethoxyquinazoline hydrochloride

→

4-[3-chloro-4-(1-methylimidazol-2-ylthio)anilino]-6,7-dimethoxyquinazoline dihydrochloride salt

Выход 71.0%

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураto reflux for 16 hours

Методика

Using an analogous procedure to that described in Example 1 except that the reaction mixture was heated to reflux for 16 hours, 4-amino-2-chlorophenyl 1-methylimidazol-2-yl sulphide was reacted with 4-chloro-6,7-dimethoxyquinazoline hydrochloride to give 4-[3-chloro-4-(1-methylimidazol-2-ylthio)anilino]-6,7-dimethoxyquinazoline dihydrochloride salt in 71% yield, m.p. 244°-246° C.;

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