3,3-difluoroazetidine;hydrochloride

COC(=O)Cc1cc(N2CC(F)(F)C2)ccn1

Rendement 39.9%750 AstraZeneca ELN dataset

Cl.O=c1c(-c2cccnc2)c[nH]n1-c1cc(N2CC(F)(F)C2)ncn1

Reaction #66188

2-[6-(3,3-Difluoroazetidin-1-yl)pyrimidin-4-yl]-4-pyridin-3-yl-1,2-dihydro-3H-pyrazol-3-one hydrochloride

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_09

CCC(C)[C@H](N)C(=O)N1CC(F)(F)C1.Cl

Reaction #78043

(S)-2-amino-1-(3,3-difluoro-azetidin-1-yl)-3-methyl-pentan-1-one hydrochloride

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2004_03

Cn1ccc2nc(C#N)c(N3CC(F)(F)C3)cc21

Reaction #162490

Rendement 29.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09

$CCCCc1cn(C(C)(C)C)s/c1=N\C(=O)C1(C)CCC(C(=O)N2CC(F)(F)C2)C1(C)C$

Reaction #163466

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09

O=C(NCCC(=O)N1CC(F)(F)C1)C(O)c1ccc(-c2noc(-c3onc(-c4ccccc4)c3C(F)(F)F)n2)cc1

Reaction #164394

(R/S)-N-(3-(3,3-difluoroazetidin-1-yl)-3-oxopropyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

Rendement 13.1%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_09

COc1c(Cl)c(C)c(C(C)=O)c(OCCN2CC(F)(F)C2)c1OCCC(C)c1ccc(F)cc1

Reaction #306645

Rendement 37.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_06

COc1c(Cl)c(C)c(C(C)=O)c(OCCN2CC(F)(F)C2)c1OCCCc1ccccc1

Reaction #306655

Rendement 20.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2012_06

C[C@@H]1CN(c2c(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)cc3c(C(=O)N4CC(F)(F)C4)noc3c2F)C[C@H](C)O1

Reaction #332643

(5-((tert-butyldiphenylsilyloxy)methyl)-6-((2R,6S)-2,6-dimethylmorpholino)-7-fluorobenzo[d]isoxazol-3-yl)(3,3-difluoroazetidin-1-yl)methanone

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02

COC(OC)c1cc2c(C(=O)N3CC(F)(F)C3)noc2c(F)c1F

Reaction #332655

(3,3-difluoroazetidin-1-yl)(5-(dimethoxymethyl)-6,7-difluorobenzo[d]isoxazol-3-yl)methanone

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02

C[C@@H]1CN(c2c(CO[Si](c3ccccc3)(c3ccccc3)C(C)(C)C)nc3c(C(=O)N4CC(F)(F)C4)noc3c2Cl)C[C@H](C)O1

Reaction #332662

(5-((tert-Butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridin-3-yl)(3,3-difluoroazetidin-1-yl)methanone

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02

O=C(NCc1nccnc1Cl)[C@H]1CC[C@H](N2CC(F)(F)C2)CC1

Reaction #332859

(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02

C[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CC(F)(F)C1

Reaction #333003

[(R)-2-(3,3-difluoro-azetidin-1-yl)-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester

Rendement 91.3%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02

CC(C)(C)NC(=O)c1cn(COCC[Si](C)(C)C)c2ncc(-c3nn(CCCN4CC(F)(F)C4)c4ccc(OC(F)F)cc34)nc12

Reaction #333601

N-tert-butyl-2-(1-(3-(3,3-difluoroazetidin-1-yl)propyl)-5-(difluoromethoxy)-1H-indazol-3-yl)-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

Rendement 98.8%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_02

$CCCCc1cn(C(C)(C)C)s/c1=N\C(=O)C1(C)CCC(C(=O)N2CC(F)(F)C2)C1(C)C$

Reaction #340827

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2011_01

Cn1nc(Cl)cc(Nc2ccc(OC(C)(C)CN3CC(F)(F)C3)cn2)c1=O

Reaction #424500

desired product

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_11

Reaction #487982

Rendement 64.0%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_06

O=C(c1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1)N1CC(F)(F)C1

Reaction #493634

(3,3-difluoroazetidin-1-yl)(4-(3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl)methanone

Rendement 57.2%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2014_06

FC1(F)CN(c2nc(Cl)nc3c2COCC3c2ccc(Cl)cc2)C1

Reaction #538245

2-chloro-8-(4-chlorophenyl)-4-(3,3-difluoro azetidin-1-yl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine

Rendement 67.9%DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_07

CC(C)(C)OC(=O)N1CCC2(CCC(N3CC(F)(F)C3)CC2)CC1

Reaction #541095

tert-Butyl 9-(3,3-difluoroazetidin-1-yl)-3-azaspiro[5.5]undecane-3-carboxylate

DOI: 10.6084/m9.figshare.5104873.v1uspto-grants-2013_07