Réaction #78043

ord-8454b09149134b8bb6599e0436bd96ab

Équation de réaction

Cl.FC1(F)CNC1
3,3-difluoro-azetidine hydrochloride
CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)O
Boc-(L)-isoleucine
Cl
HCl
→
CCC(C)[C@H](N)C(=O)N1CC(F)(F)C1.Cl
(S)-2-amino-1-(3,3-difluoro-azetidin-1-yl)-3-methyl-pentan-1-one hydrochloride

Réactifs

—
Example 1
Cl.FC1(F)CNC1
3,3-difluoro-azetidine hydrochloride
CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)O
Boc-(L)-isoleucine
Cl
HCl

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

(S)-2-amino-1-(3,3-difluoro-azetidin-1-yl)-3-methyl-pentan-1-one hydrochloride was prepared by coupling 3,3-difluoro-azetidine hydrochloride (WO 0047582) with Boc-(L)-isoleucine followed by HCl deprotection as analogously described in Example 1 (mp 195° C. dec.).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06710040B1uspto-grants-2004_03