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CC1=CSC=N1

COc1cc(OC)c(-c2csc(C)n2)cc1/C=C/C(=O)c1ccc(C(=O)O)cc1

Reaction #10786

DOI: 10.6084/m9.figshare.5104873.v1

COc1cc(OC)c2c(CNC(=O)OC(C)(C)C)ncc(Nc3nc(C)cs3)c2c1

Reaction #42926

[6,8-dimethoxy-4-(4-methyl-thiazol-2-ylamino)isoquinolin-1-ylmethyl]carbamic acid tert-butyl ester

DOI: 10.6084/m9.figshare.5104873.v1

COc1cc(OC)c2c(CN)ncc(Nc3nc(C)cs3)c2c1.Cl

Reaction #42927

(1-aminomethyl-6,8-dimethoxy-isoquinolin-4-yl)-(4-methyl-thiazol-2-yl)amine hydrochloride salt

Ausbeute 53.0%DOI: 10.6084/m9.figshare.5104873.v1

CCOC(=O)c1csc(Nc2cnc(CNC(=O)OC(C)(C)C)c3c(OC)cc(OC)cc23)n1

Reaction #42928

2-[1-(tert-butoxycarbonylamino-methyl)-6,8-dimethoxy-isoquinolin-4-ylamino]thiazole-4-carboxylic acid ethyl ester

Ausbeute 42.1%DOI: 10.6084/m9.figshare.5104873.v1

CCOC(=O)c1csc(Nc2cnc(CN)c3c(OC)cc(OC)cc23)n1.Cl

Reaction #42929

2-(1-aminomethyl-6,8-dimethoxy-isoquinolin-4-ylamino)thiazole-4-carboxylic acid ethyl ester hydrochloride salt

Ausbeute 73.0%DOI: 10.6084/m9.figshare.5104873.v1

COc1cc2c(Nc3nc(-c4ccccc4)cs3)cnc(CN)c2cc1OC.Cl

Reaction #42946

(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-(4-phenyl-thiazol-2-yl)amine hydrochloride salt

Ausbeute 71.0%DOI: 10.6084/m9.figshare.5104873.v1

COc1cc2c(Nc3nc(C)cs3)cnc(CNC(=O)OC(C)(C)C)c2cc1OC

Reaction #42947

[6,7-dimethoxy-4-(4-methyl-thiazol-2-ylamino)isoquinolin-1-ylmethyl]carbamic acid tert-butyl ester

DOI: 10.6084/m9.figshare.5104873.v1

COc1cc2c(Nc3nc(C)cs3)cnc(CN)c2cc1OC.Cl

Reaction #42948

(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-(4-methyl-thiazol-2-yl)amine hydrochloride salt

Ausbeute 75.0%DOI: 10.6084/m9.figshare.5104873.v1

CCOC(=O)c1csc(Nc2cnc(CNC(=O)OC(C)(C)C)c3cc(OC)c(OC)cc23)n1

Reaction #42949

2-[1-(tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinolin-4-ylamino]thiazole-4-carboxylic acid ethyl ester

DOI: 10.6084/m9.figshare.5104873.v1

CCOC(=O)c1csc(Nc2cnc(CN)c3cc(OC)c(OC)cc23)n1.Cl

Reaction #42950

2-(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-ylamino)thiazole-4-carboxylic acid ethyl ester hydrochloride salt

Ausbeute 93.0%DOI: 10.6084/m9.figshare.5104873.v1

COc1cc(OC)c2c(CN3C(=O)c4ccccc4C3=O)ncc(Nc3nc(C(=O)O)cs3)c2c1

Reaction #42972

Ausbeute 75.0%DOI: 10.6084/m9.figshare.5104873.v1

CNC(=O)c1csc(Nc2cnc(CN)c3c(OC)cc(OC)cc23)n1

Reaction #42973

Ausbeute 60.0%DOI: 10.6084/m9.figshare.5104873.v1

COC(=O)c1csc(NC(=O)[C@H]([C@@H](C)c2ccccc2)N2C(=O)N[C@H](c3ccc(NC(C)=O)cc3)C2=O)n1

Reaction #61121

2-{(2S,3S)-2-[(R)-4-(4-acetylamino-phenyl)-2,5-dioxo-imidazolidin-1-yl]-3-phenyl-butyrylamino}-thiazole-4-carboxylic acid methyl ester

Ausbeute 119.9%DOI: 10.6084/m9.figshare.5104873.v1

CCOC(=O)c1sc2nc(C)c(CC)c(=O)n2c1C

Reaction #92917

6-ethyl-3,7-dimethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidine-2-carboxylic acid, ethyl ester

DOI: 10.6084/m9.figshare.5104873.v1

$COc1ccc(Cl)cc1C(=O)/N=c1\scc(C(C)(C)C)n1C[C@H]1CCCO1$

Reaction #165709

DOI: 10.6084/m9.figshare.5104873.v1

O=C(O)c1csc(C2CCN(C(=O)Cn3ccc(C(F)(F)F)n3)CC2)n1

Reaction #173204

DOI: 10.1039/C8SC04228D

Cc1c(Cl)cccc1S(=O)(=O)Nc1nc(CCN2CCOC(O)C2=O)cs1

Reaction #173726

DOI: 10.1039/C8SC04228D

Reaction #178233

DOI: 10.1039/C8SC04228D

CCNC(=O)Nc1nc(C)c(-c2cc(Cl)c(S(N)(=O)=O)c(Cl)c2)s1

Reaction #182375

DOI: 10.1039/C8SC04228D

CCCN(CCC)Cc1csc(-c2ncn3c2CN(C)C(=O)c2ccccc2-3)n1

Reaction #191715

DOI: 10.1039/C8SC04228D

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