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1224849

O=C(O)COC[C@@H](Nc1ncnc2cc(C(=O)N3CCCC3)c(Cl)cc12)c1nc2cc(Cl)ccc2[nH]1
Reaction #62419
6-chloro-4-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-2-(hydroxycarbonylmethoxy)-ethylamino]-7-(pyrrolidin-1-yl-carbonyl)-quinazoline
DOI: 10.6084/m9.figshare.5104873.v1
COC[C@H](Nc1nc(N2CCN(c3ccc(Cl)cc3)CC2)nc2c1S(=O)CC2)c1nc2ccc(Cl)cc2[nH]1
Reaction #157289
product
Ausbeute 37.8%DOI: 10.6084/m9.figshare.5104873.v1
C[C@@H](O)[C@H](Nc1nc(N2CCN(c3ccc(Cl)cc3)CC2)nc2c1S(=O)CC2)c1nc2ccc(Cl)cc2[nH]1
Reaction #157290
product
DOI: 10.6084/m9.figshare.5104873.v1
Cc1cc(C(=O)NC(c2nc3cc(Cl)ccc3[nH]2)C(C)O)ccc1C(=O)N1CC=CC1
Reaction #174572
DOI: 10.1039/C8SC04228D
COCC(NC(=O)c1ccc(C(=O)N2CC=CC2)c(C)c1)c1nc2cc(Cl)ccc2[nH]1
Reaction #182063
DOI: 10.1039/C8SC04228D
O=C(NC(CO)c1nc2cc(Cl)ccc2[nH]1)c1ccc(C(=O)N2CC=CC2)c(Br)c1
Reaction #213097
DOI: 10.1039/C8SC04228D
COCC(NC(=O)c1ccc(C(=O)N2CCCC2)c(C)c1)c1nc2cc(Cl)ccc2[nH]1
Reaction #226861
DOI: 10.1039/C8SC04228D
Cc1cc(C(=O)NC(COCC(=O)OC(C)(C)C)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1
Reaction #235552
DOI: 10.1039/C8SC04228D
O=C(O)COCC(Nc1ncnc2cc(C(=O)N3CCCC3)c(Cl)cc12)c1nc2cc(Cl)ccc2[nH]1
Reaction #252583
DOI: 10.1039/C8SC04228D
O=C(NC(CO)c1nc2cc(Cl)ccc2[nH]1)c1ccc(C(=O)N2CC=CC2)c(Cl)c1
Reaction #261102
DOI: 10.1039/C8SC04228D
COCC(NC(=O)c1ccc(N2CCCCC2=O)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1
Reaction #288252
DOI: 10.1039/C8SC04228D
CCOCC(NC(=O)c1ccc(C(=O)N2CC=CC2)c(Br)c1)c1nc2cc(Cl)ccc2[nH]1
Reaction #369422
DOI: 10.1039/C8SC04228D
Cc1cc(C(=O)NC(COCC(=O)O)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1
Reaction #397839
DOI: 10.1039/C8SC04228D
Cc1cc(C(=O)NC(c2nc3cc(Cl)ccc3[nH]2)C(C)OC(C)(C)C)ccc1C(=O)N1CC=CC1
Reaction #404820
DOI: 10.1039/C8SC04228D
COC[C@H](NC(=O)c1ccc(N2CCCCC2=O)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1
Reaction #638372
3-chloro-N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethyl]-4-(piperidin-2-on-1-yl)-benzamide
DOI: 10.6084/m9.figshare.5104873.v1
COC[C@H](NC(=O)c1ccc(N2CCOCCC2=O)c(C)c1)c1nc2cc(Cl)ccc2[nH]1
Reaction #638417
N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethyl]-3-methyl-4-(5-oxo-[1,4]oxazepan-4-yl)-benzamide
DOI: 10.6084/m9.figshare.5104873.v1
COC[C@H](NC(=O)c1ccc(N2CCOCC2=O)c(F)c1)c1nc2cc(Cl)ccc2[nH]1
Reaction #638432
N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethyl]-3-fluoro-4-(morpholin-3-on-4-yl)-benzamide
DOI: 10.6084/m9.figshare.5104873.v1
COC[C@H](NC(=O)c1ccc(N2C(=O)COCC2C)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1
Reaction #638443
3-chloro-N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethyl]-4-(5-methyl-morpholin-3-on-4-yl)-benzamide
DOI: 10.6084/m9.figshare.5104873.v1
C=CCOCC(NC(=O)c1ccc(C(=O)N2CC=CC2)c(C)c1)c1nc2cc(Cl)ccc2[nH]1
Reaction #751447
DOI: 10.1039/C8SC04228D
C#CCOCC(NC(=O)c1ccc(C(=O)N2CC=CC2)c(Br)c1)c1nc2cc(Cl)ccc2[nH]1
Reaction #775187
DOI: 10.1039/C8SC04228D
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