Reaktion #638443

ord-b1b169029f1342f8be7ec5f674ab08b6

Reaktionsgleichung

CC1COCC(=O)N1c1ccc(C(=O)O)cc1Cl
3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoic acid
COC[C@H](N)c1nc2cc(Cl)ccc2[nH]1
(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethylamine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU
→
COC[C@H](NC(=O)c1ccc(N2C(=O)COCC2C)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1
3-chloro-N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethyl]-4-(5-methyl-morpholin-3-on-4-yl)-benzamide

Edukte

CC1COCC(=O)N1c1ccc(C(=O)O)cc1Cl
3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoic acid
COC[C@H](N)c1nc2cc(Cl)ccc2[nH]1
(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethylamine
CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
TBTU

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared analogously to Example 1f from 3-chloro-4-(5-methyl-morpholin-3-on-4-yl)-benzoic acid and (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxy-ethylamine with TBTU and TEA in DMF.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07947700B2uspto-grants-2011_05