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1112694

CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=CCS[C@H]12)c1nc(NC(=O)CCl)sc1Cl

Reaction #214081

7β-[2-methoxyimino-2-(2-chloroacetamido-5-chloro-4-thiazolyl)acetamido]-3-cephem-4-carboxylic acid diphenylmethyl ester

المردود 75.1%DOI: 10.6084/m9.figshare.5104873.v1

CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)OC(c3ccccc3)c3ccccc3)=CCS[C@H]12)c1nc(N)sc1Cl

Reaction #214083

7β-[2-(2-amino-5-chloro-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid diphenylmethyl ester

DOI: 10.6084/m9.figshare.5104873.v1

CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=CCS[C@H]12)c1nc(N)sc1Cl

Reaction #214085

7β-[2-(2-amino-5-chloro-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid

المردود 74.0%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #214086

7β-[2-methoxyimino-2-(2-amino-5-chloro-4-thiazolyl)acetamido]-3-cephem-4-carboxylic acid

المردود 78.6%DOI: 10.6084/m9.figshare.5104873.v1

Nc1nc(/C(=N/OC(c2ccccc2)(c2ccccc2)c2ccccc2)C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(S)CS[C@H]23)c(Cl)s1

Reaction #430120

foam

المردود 190.7%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #464573

foam

المردود 190.7%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #465703

foam

المردود 190.7%DOI: 10.6084/m9.figshare.5104873.v1

$COc1ccc(COC(=O)[C@H](CC(=O)OC(C)(C)C)O/N=C(\C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CCl)CS[C@H]23)c2nc(NC(=O)OC(C)(C)C)sc2Cl)cc1$

Reaction #613094

(S)-4-tert-butyl 1-(4-methoxybenzyl) 2-(((Z)-(2-(((6R,7R)-2-((benzhydryloxy)carbonyl)-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)-5-chlorothiazol-4-yl)-2-oxoethylidene)amino)oxy)succinate

المردود 95.0%DOI: 10.6084/m9.figshare.5104873.v1

$COc1ccc(COC(=O)[C@H](CC(=O)OC(C)(C)C)O/N=C(\C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CCl)C[S@@](=O)[C@H]23)c2nc(NC(=O)OC(C)(C)C)sc2Cl)cc1$

Reaction #613095

(S)-4-tert-butyl 1-(4-methoxybenzyl) 2-(((Z)-(2-(((5R,6R,7R)-2-((benzhydryloxy)carbonyl)-3-(chloromethyl)-5-oxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)-5-chlorothiazol-4-yl)-2-oxoethylidene)amino)oxy)succinate

المردود 94.0%DOI: 10.6084/m9.figshare.5104873.v1

$COc1ccc(COC(=O)[C@H](CC(=O)OC(C)(C)C)O/N=C(\C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CI)C[S@@](=O)[C@H]23)c2nc(NC(=O)OC(C)(C)C)sc2Cl)cc1$

Reaction #613096

(S)-4-tert-butyl 1-(4-methoxybenzyl) 2-(((Z)-(2-(((5R,6R,7R)-2-((benzhydryloxy)carbonyl)-3-(iodomethyl)-5-oxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)amino)-1-(2-((tert-butoxycarbonyl)amino)-5-chlorothiazol-4-yl)-2-oxoethylidene)amino)oxy)succinate

المردود 59.9%DOI: 10.6084/m9.figshare.5104873.v1

$CCn1cc(C[N+]2(CC3=C(C(=O)[O-])N4C(=O)[C@@H](NC(=O)/C(=N\O[C@@H](CC(=O)O)C(=O)O)c5nc(N)sc5Cl)[C@H]4SC3)CCCC2)c(=O)c2c(Cl)c(O)c(O)cc21$

Reaction #613097

(6R,7R)-7-((Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(((S)-1,2-dicarboxyethoxy)imino)acetamido)-3-((1-((5-chloro-1-ethyl-6,7-dihydroxy-4-oxo-1,4-dihydroquinolin-3-yl)methyl)pyrrolidin-1-ium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

المردود 58.0%DOI: 10.6084/m9.figshare.5104873.v1

CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CCl)CS[C@H]23)c(Cl)s1

Reaction #613100

(6R,7R)-benzhydryl 7-((Z)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)-5-chlorothiazol-4-yl)acetamido)-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

المردود 89.0%DOI: 10.6084/m9.figshare.5104873.v1

CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CCl)C[S@@](=O)[C@H]23)c(Cl)s1

Reaction #613101

(5R,6R,7R)-benzhydryl 7-((Z)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)-5-chlorothiazol-4-yl)acetamido)-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide

المردود 91.6%DOI: 10.6084/m9.figshare.5104873.v1

CC(C)(C)OC(=O)Nc1nc(/C(=N/OC(C)(C)C(=O)OC(C)(C)C)C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(CI)C[S@@](=O)[C@H]23)c(Cl)s1

Reaction #613102

(5R,6R,7R)-benzhydryl 7-((Z)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)-5-chlorothiazol-4-yl)acetamido)-3-(iodomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide

المردود 67.4%DOI: 10.6084/m9.figshare.5104873.v1

C=CC1=C(C(=O)OC(c2ccccc2)c2ccccc2)N2C(=O)C(NC(=O)C(=NOC(C)C(=O)OC(C)(C)C)c3nc(N)sc3Cl)[C@H]2SC1

Reaction #656615

Benzhydryl 7-[2-(1-tert-butoxycarbonylethoxyimino)-2-(2-amino-5-chlorothiazol-4-yl)acetamido]-3-vinyl-3-cephem-4-carboxylate

المردود 92.4%DOI: 10.6084/m9.figshare.5104873.v1

C=CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOC(C)C(=O)O)c3nc(N)sc3Cl)[C@H]2SC1

Reaction #656617

7-[2-(1-carboxyethoxyimino)-2-(2-amino-5-chlorothiazol-4-yl)acetamido]-3-vinyl-3-cephem-4-carboxylic acid

المردود 46.9%DOI: 10.6084/m9.figshare.5104873.v1

Nc1nc(/C(=N/OC2C=CCC2)C(=O)N[C@@H]2C(=O)N3C(C(=O)OC(c4ccccc4)c4ccccc4)=C(SCc4cn[nH]c4)CS[C@H]23)c(Cl)s1

Reaction #706418

diphenylmethyl 7β-[2-(2-amino-5-chlorothiazol-4-yl)-2-(Z)-(2-cyclopenten-1-yloxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylate

المردود 63.1%DOI: 10.6084/m9.figshare.5104873.v1

Nc1nc(/C(=N/O)C(=O)N[C@@H]2C(=O)N3C(C(=O)O)=C(SCc4cn[nH]c4)CS[C@H]23)c(Cl)s1

Reaction #706419

7β-[2-(2-amino-5-chlorothiazol-4-yl)-2-(Z)-(hydroxyimino)acetamido]-3-[(pyrazol-4-yl)methylthio]-3-cephem-4-carboxylic acid

المردود 35.5%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #992664

Benzhydryl 7-[2-(1-tert-butoxycarbonylethoxyimino)-2-(2-amino-5-chlorothiazol-4-yl)acetamido]-3-vinyl-3-cephem-4-carboxylate

المردود 92.4%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #992666

7-[2-(1-carboxyethoxyimino)-2-(2-amino-5-chlorothiazol-4-yl)-acetamido]-3-vinyl-3-cephem-4-carboxylic acid

المردود 46.9%DOI: 10.6084/m9.figshare.5104873.v1

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