تفاعل #214083

معادلة التفاعل

7β-[2-(2-amino-5-chloro-4-thiazolyl)-2-methoxyiminoacetamido]-3-chloro-3-cephem-4-carboxylic acid diphenylmethyl ester

acetic acid

→

7β-[2-(2-amino-5-chloro-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid diphenylmethyl ester

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture is filtered
2. 2
   workup.ADDITIONpoured into iced water
3. 3
   استخلاصextracted with ethyl acetate
4. 4
   غسيلThe extract solution is washed with aqueous sodium hydrogen carbonate solution and water
5. 5
   أخرىdried
6. 6
   تركيزconcentrated

الإجراء التجريبي

To a solution of 7β-[2-(2-amino-5-chloro-4-thiazolyl)-2-methoxyiminoacetamido]-3-chloro-3-cephem-4-carboxylic acid diphenylmethyl ester (180 mg) in dichloromethane (5 ml) are added zinc powder (120 mg) and acetic acid (1 ml), and the mixture is stirred at -10° C. for 10 minutes. The reaction mixture is filtered, poured into iced water and extracted with ethyl acetate. The extract solution is washed with aqueous sodium hydrogen carbonate solution and water, dried and concentrated. Conventional work-up of obtained residue affords 7β-[2-(2-amino-5-chloro-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid diphenylmethyl ester. Similarly prepared are compounds of Table 1.

المصدر