反应 #9969

反应方程式

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine

4-formylpyridine

magnesium sulfate

→

title compound

收率 100.7%

(±)-7-(Pyridin-4-yl)methyleneamino-1,2,3,5,6,7,8,8a-octahydroindolizine

收率 100.7%

溶剂

toluene

反应条件

后处理

1. 1
   过滤At the end of this time, the reaction mixture was filtered
2. 2
   其他to remove the catalyst
3. 3
   浓缩the filtrate was concentrated by evaporation under reduced pressure

实验过程

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine (4.91 g (35.0 mmol), prepared as described in 1)) was dissolved in toluene (95 ml). To the solution were added 4-formylpyridine (3.34 ml, 35.0 mmol) and anhydrous magnesium sulfate (3.75 g, 31.2 mmol), and the resulting mixture was stirred at 70° C. for 3 hours. At the end of this time, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated by evaporation under reduced pressure, to give the title compound (8.08 g) as a pale yellow oil (yield quantitative).

来源