反应 #993

反应方程式

Chloroacetylchloride

2-aminopyridine

diisopropylethylamine

→

brown solid

收率 80.1%

2-Chloro-N-(2-pyridinyl)acetamide

收率 80.1%

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他the temperature below 5° C
2. 2
   过滤was filtered
3. 3
   洗涤washed with water
4. 4
   干燥The organic layer was dried (MgSO4)
5. 5
   其他evaporated under reduced pressure

实验过程

Chloroacetylchloride (60 g, 0.53M) was added with stirring to a mixture of 2-aminopyridine (50 g, 0.53M) and diisopropylethylamine (75 ml, 0.53M) in dichloromethane (500 ml) keeping the temperature below 5° C. After the reaction mixture was warmed to room temperature it was filtered and washed with water. The organic layer was dried (MgSO4) and evaporated under reduced pressure to give 72.6 g of a brown solid.

来源