反应 #992706

反应方程式

5-aminouracil

4,4′-difluorobenzophenone

→

N-(5-uracil-yl)-4,4′-difluorobenzophenone imine

溶剂

—

hexanes

N-methylpyrrolidone N-cyclohexylpyrrolidone

反应条件

后处理

1. 1
   其他In a round bottom flask equipped with an overhead stirrer
2. 2
   workup.ADDITIONwas added to fully induce precipitation
3. 3
   其他the solid was isolated by filtration
4. 4
   其他twice recrystallized from isopropanol
5. 5
   洗涤The product was rinsed with isopropanol, suction
6. 6
   其他dried
7. 7
   其他vacuum dried in an oven overnight

实验过程

In a round bottom flask equipped with an overhead stirrer, 1.16 grams (0.009 mole) of 5-aminouracil was charged along with 6 grams (0.027 mole) of 4,4′-difluorobenzophenone and a N-methylpyrrolidone/N-cyclohexylpyrrolidone solvent mixture (50/50, 20 milliliters). The reaction mixture was then heated to 180° C. for 3 days. A charge of hexanes (100 milliliters) was added to fully induce precipitation, and the solid was isolated by filtration and twice recrystallized from isopropanol. The product was rinsed with isopropanol, suction dried, and vacuum dried in an oven overnight.

来源