反应 #985279

反应方程式

p-Nitro-β-phenylalanine

sodium hydroxide

acetic anhydride

sodium hydroxide

HCl

→

acetyl-p-nitro-β-phenylalanine

收率 96.9%

溶剂

water

反应条件

后处理

1. 1
   workup.STIRRINGstirred for one hour
2. 2
   其他the resulting precipitated crystal
3. 3
   过滤was filtered
4. 4
   其他dried under reduced pressure

实验过程

p-Nitro-β-phenylalanine (10.0 g, 48 mmol) was mixed with 40 ml of water and adjusted to pH 14 with 25% sodium hydroxide aqueous solution. After being cooled to 5° C., 10.7 ml of acetic anhydride (105 mmol) and 25% sodium hydroxide aqueous solution were simultaneously dropped into the mixture to keep it at a pH range of 11.5˜12 and the resulting mixture was stirred for 1.5 hours at a room temperature. After the mixture was adjusted to pH 2 with conc. HCl and stirred for one hour, the resulting precipitated crystal was filtered and dried under reduced pressure to give 11.6 g of acetyl-p-nitro-β-phenylalanine at a yield of 96.9%.

来源