反应 #985265

反应方程式

charcoal

Cefdinir

sodium bicarbonate

→

Cefdinir monohydrate

溶剂

water

反应条件

后处理

1. 1
   洗涤eluted with 20% aqueous acetone
2. 2
   浓缩concentrated to 200 ml
3. 3
   其他was adjusted to pH 2.2 at 15° C. with 10% hydrochloric acid
4. 4
   过滤The resultant crystals were collected by filtration
5. 5
   洗涤washed with water
6. 6
   其他dried

实验过程

The monohydrate was prepared as follows: Cefdinir (20.0 g) was added to water (200 ml) and the mixture was adjusted to pH 6.0 with saturated sodium bicarbonate aqueous solution. The resultant solution was subjected to a column chromatography on activated charcoal and eluted with 20% aqueous acetone. Fractions were combined and then concentrated to 200 ml. This solution was adjusted to pH 2.2 at 15° C. with 10% hydrochloric acid and stirred at 0° C. for 30 minutes. The resultant crystals were collected by filtration, washed with water and dried to give crystals of Cefdinir monohydrate. The present inventors investigated physicochemical properties for Cefdinir monohydrate and crystal form A. The results are described below.

来源