反应 #985264

反应方程式

dimethyl-5-nitroisophthalate

ethanolamine

→

N,N′-bis(2-hydroxyethyl)-5-nitro-1,3-benzenedicarboxamide

收率 67.3%

溶剂

methanol

反应条件

后处理

1. 1
   温度was refluxed for 48 hours
2. 2
   其他The solvent was removed by evaporation under reduced pressure
3. 3
   其他The crude product was purified by crystallization from EtOAC

实验过程

A solution containing dimethyl-5-nitroisophthalate (23.9 g, 100 mmol) and ethanolamine (13.4 g, 220 mmol) in methanol (300 mL) was refluxed for 48 hours. The solvent was removed by evaporation under reduced pressure. The crude product was purified by crystallization from EtOAC:MeOH 1 ml v/v) to afford 20.0 g of pure N,N′-bis(2-hydroxyethyl)-5-nitro-1,3-benzenedicarboxamide as white crystals. m.p.=151.3-151.4° C., uncorrected

来源