反应 #9820

ord-a28dfc986e8549b3bda0a7e2c9a0bc50

反应方程式

O=C1OC(=O)c2cc([N+](=O)[O-])ccc21
4-Nitro-phthalic anhydride
CC(C)(N)CO
2-amino-2-methylpropanol
O
water
→
CC(C)(CO)N1Cc2ccc([N+](=O)[O-])cc2C1
2-(1,1-dimethyl-2-hydroxyethyl)-5-nitro-2,3-dihydro-1H-isoindol

反应物

O=C1OC(=O)c2cc([N+](=O)[O-])ccc21
4-Nitro-phthalic anhydride
CC(C)(N)CO
2-amino-2-methylpropanol
O
water

试剂

无

溶剂

ClCCl
CH2Cl2

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    温度After cooling
  2. 2
    其他the organic phase separated
  3. 3
    浓缩concentrated
  4. 4
    其他purified by chromatography on silica (eluent CH2Cl2/MeOH 97/3)

实验过程

20 g of 4-Nitro-phthalic anhydride and 8.94 g of 2-amino-2-methylpropanol were heated to 170° C. for 30 min. After cooling, water and CH2Cl2 were added, and the organic phase separated, concentrated and purified by chromatography on silica (eluent CH2Cl2/MeOH 97/3).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07091345B2uspto-grants-2006_08