反应 #973

反应方程式

N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine

N-(5-Fluoro-2-nitrophenyl)-S-methyl-L-cysteine

sodium methoxide

→

N-(5-Methoxy-2-nitrophenyl)-S-methyl-L-cysteine

溶剂

methanol

反应条件

后处理

1. 1
   温度while cooling by means of an ice bath
2. 2
   温度The mixture is then heated
3. 3
   温度to reflux for 2 hours
4. 4
   workup.STIRRINGwhile stirring

实验过程

27 g of N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine (0.1 mol) from Example 1 are dissolved in 150 ml of absolute methanol in a four-necked flask, and 14.4 g of 95% sodium methoxide (0.25 mmol) are added in portions, within the space of 20 minutes and under argon, to this solution while stirring well and while cooling by means of an ice bath. The mixture is then heated to reflux for 2 hours while stirring. TLC monitoring then indicates that the reaction is complete.

来源