反应 #969877

反应方程式

6-aminoquinoline

1-hydroxibenzotriazol

Z-Val-Pro-OH

N,N′-diisopropylcarbodiimide

→

Z-Val-Pro 6-aminoquinoline

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他was continued until the complete disappearance of the starting material (overnight)
2. 2
   其他Then, the solvent was evaporated
3. 3
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
4. 4
   洗涤washed with citric acid (10%), NaHCO3 (10%) and brine
5. 5
   干燥The organic layer was dried (Na2SO4)
6. 6
   其他evaporated
7. 7
   其他leaving a residue that
8. 8
   其他was purified by CCTLC on the chromatotron with hexane/ethyl acetate (1:4)
9. 9
   其他to yield H (20
10. 10
    其他yield

实验过程

A solution of Z-Val-Pro-OH (217.4 mg, 0.62 mmol) in dichloromethane (1.5 mL), was successively treated at room temperature. with 1-hydroxibenzotriazol (84.3 mg, 0.62 mmol), N,N′-diisopropylcarbodiimide (97.2 μL, 0.62 mmol) and 6-aminoquinoline (75 mg, 0.52 mmol). The stirring was continued until the complete disappearance of the starting material (overnight). Then, the solvent was evaporated, the residue was dissolved in ethyl acetate and washed with citric acid (10%), NaHCO3 (10%) and brine. The organic layer was dried (Na2SO4) and evaporated leaving a residue that was purified by CCTLC on the chromatotron with hexane/ethyl acetate (1:4) to yield H (20 yield

来源