反应 #969876

反应方程式

piperidine

Fmoc-Val-Pro doxorubicin

→

compound G

收率 50.0%

H-Val-Pro doxorubicin

收率 50.0%

溶剂

dimethylformamide

反应条件

后处理

1. 1
   其他form red to purple)
2. 2
   其他Then, the reaction mixture was evaporated to dryness under reduced pressure
3. 3
   其他the residue thus obtained
4. 4
   其他was purified by reverse phase chromatography with water/acetonitrile (70:1)

实验过程

A solution of piperidine in dimethylformamide 50% (1.92 mL) was added to Fmoc-Val-Pro-doxorubicin (F) (29.7 mg, 0.03 mmol) and the reaction mixture was stirred at room temperature for 1 minute (the reaction colour changes form red to purple). Then, the reaction mixture was evaporated to dryness under reduced pressure and the residue thus obtained was purified by reverse phase chromatography with water/acetonitrile (70:1) to give the deprotected compound G (50% yield)

来源