反应 #964545

反应方程式

1-(1,3-thiazol-2-yl)ethanone

p-TsOH

methanol

→

2-(1,1-dimethoxyethyl)-1,3-thiazole

收率 75.6%

反应条件

后处理

1. 1
   温度was refluxed for 18 h
2. 2
   浓缩After concentration
3. 3
   其他the residue was partitioned between sat. NaHCO3 and ether
4. 4
   洗涤The organic layers were washed with brine
5. 5
   干燥dried over Na2SO4
6. 6
   浓缩concentrated

实验过程

A mixture of 1-(1,3-thiazol-2-yl)ethanone (35 g, 0.28 mol), anhydrous p-TsOH (50 g, 0.29 mol) and trimethyl ortheformate (175 ml) in methanol (500 ml) was refluxed for 18 h. After concentration, the residue was partitioned between sat. NaHCO3 and ether. The organic layers were washed with brine, dried over Na2SO4 and concentrated to give 36 g (75.6%) of 2-(1,1-dimethoxyethyl)-1,3-thiazole as an oil.

来源