反应 #96262

反应方程式

1,3-dichloroacetone

(N-n-butylamidino)thiourea

→

2-(2-n-butylguanidino)-4-chloromethylthiazole hydrochloride

溶剂

acetone

acetone

反应条件

后处理

1. 1
   温度cooled in ice
2. 2
   过滤the precipitated solid filtered off
3. 3
   洗涤washed with acetone

实验过程

A solution of 1,3-dichloroacetone (3.02 g.) in acetone (10 ml.) was added to a stirred suspension of (N-n-butylamidino)thiourea (4.04 g.) in acetone (25 ml.) at room temperature. The resulting clear pale yellow solution was stirred for three days, then cooled in ice, and the precipitated solid filtered off and washed with acetone to give 2-(2-n-butylguanidino)-4-chloromethylthiazole hydrochloride.

来源