反应 #96254

反应方程式

amidinothiourea

1,3-dichloroacetone

→

2-guanidino-4-chloromethylthiazole hydrochloride

溶剂

acetone

acetone

反应条件

后处理

1. 1
   过滤was filtered off
2. 2
   洗涤washed with acetone
3. 3
   其他Crystallization from ethanol

实验过程

A suspension of amidinothiourea (16.8 g.) in acetone (75 ml.) was treated with 1,3-dichloroacetone (18 g.) in acetone (60 ml.). There was a slight exotherm and the crystalline suspension gradually changed to a fine white solid. After stirring overnight at room temperature the solid was filtered off and washed with acetone. Crystallization from ethanol gave 2-guanidino-4-chloromethylthiazole hydrochloride, m.p. 191°-193° C.

来源