反应 #962

反应方程式

(3RS)-1-benzyl-3-chloromethyl pyrrolidine

sodium cyanide

Water

→

product

收率 92.0%

(3RS)-1-benzyl-3-cyanomethyl pyrrolidine

收率 92.0%

溶剂

dimethyl sulfoxide

反应条件

后处理

1. 1
   萃取the mixture was extracted three times with ethyl acetate
2. 2
   洗涤The combined organic layer was washed with brine
3. 3
   干燥dried (Na2SO4)
4. 4
   过滤filtered
5. 5
   其他evaporated

实验过程

16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.

来源