反应 #96164

反应方程式

[(tetrahydro-2H-pyran-2-ylidene)methyl]triphenylphosphonium chloride

cyclohexanecarbaldehyde

→

1-cyclohexyl-7-chloro-1-hepten-3-one

溶剂

xylene

反应条件

后处理

1. 1
   温度This suspension was maintained under a nitrogen atmosphere
2. 2
   温度was refluxed for about 4 hours until a clear solution
3. 3
   其他formed
4. 4
   其他xylene was removed at a temperature of about 60° C. and under reduced pressure
5. 5
   其他leaving a product mixture
6. 6
   其他This mixture was separated chromatographically on a silica column

实验过程

2 parts of [(tetrahydro-2H-pyran-2-ylidene)methyl]triphenylphosphonium chloride and 1.2 parts of cyclohexanecarbaldehyde were combined in 45 parts of xylene. This suspension was maintained under a nitrogen atmosphere and was refluxed for about 4 hours until a clear solution formed. After cooling the solution to room temperature, xylene was removed at a temperature of about 60° C. and under reduced pressure, leaving a product mixture. This mixture was separated chromatographically on a silica column using as the elution solvent 50 percent by volume of Skelly B in benzene, to yield 1-cyclohexyl-7-chloro-1-hepten-3-one.

来源