反应 #96062

反应方程式

N-methyl-N'-phenylchloroformamidine hydrochloride

sodium hydroxide

→

carbodiimide

N-Methyl-N'-phenylcarbodiimide

溶剂

chloroform

反应条件

后处理

1. 1
   其他the organic phase is separated off
2. 2
   萃取the aqueous phase is extracted twice more with chloroform
3. 3
   干燥the combined organic phases are dried over K2CO3
4. 4
   过滤After filtering off the desiccant
5. 5
   其他the solution is subjected to further reaction

实验过程

A suspension of 2.05 g of N-methyl-N'-phenylchloroformamidine hydrochloride in 8 ml of chloroform is added, at 10°-12° C., to 6 g of 20% strength sodium hydroxide solution. The mixture is stirred for 10 minutes, the organic phase is separated off, the aqueous phase is extracted twice more with chloroform and the combined organic phases are dried over K2CO3. After filtering off the desiccant, the solution is subjected to further reaction without isolating the carbodiimide.

来源