反应 #955942

反应方程式

methionine

→

Bis[2-(methylthio)ethyl]-2,5-piperazinedione

3,6-bis[2-(methylthio)ethyl]-2,5-piperazinedione

溶剂

water

反应条件

后处理

1. 1
   workup.STIRRINGstirred at 160° C. for 6 hours, during which the pressure
2. 2
   温度increased to 15 bar
3. 3
   温度The autoclave was then cooled in an ice bath
4. 4
   过滤the resulting suspension was filtered
5. 5
   洗涤the solid was washed with 75 ml of water
6. 6
   其他Finally, the solid was dried in a vacuum
7. 7
   其他drying oven at 50° C. overnight

实验过程

A suspension of 13.4 g (0.09 mol) of methionine, 17.2 g (0.09 mol, purity: 91%) of methioninehydantoin (IId) and 150 g of water were introduced into a 200 ml Roth steel autoclave with magnetic stirring and stirred at 160° C. for 6 hours, during which the pressure increased to 15 bar. From time to time, the autoclave was decompressed until the pressure settled at a constant 10 bar. The autoclave was then cooled in an ice bath, and the resulting suspension was filtered and the solid was washed with 75 ml of water. Finally, the solid was dried in a vacuum drying oven at 50° C. overnight. Bis[2-(methylthio)ethyl]-2,5-piperazinedione (III) was isolated as yellowish white crystals.

来源