反应 #955938

反应方程式

4-chloro-2-methoxybenzoic acid

MeOH

→

methyl 4-chloro-2-methoxybenzoate

收率 96.0%

溶剂

H2SO4

反应条件

后处理

1. 1
   温度was refluxed overnight
2. 2
   其他MeOH was evaporated
3. 3
   萃取the residue was extracted to EtOAc
4. 4
   洗涤successively washed with water and brine
5. 5
   干燥dried over MgSO4
6. 6
   过滤filtered
7. 7
   其他evaporated

实验过程

A suspension of 4-chloro-2-methoxybenzoic acid (5 g, 27 mmol) in MeOH (18 mL) and conc. H2SO4 (1.5 mL) was refluxed overnight. MeOH was evaporated and the residue was extracted to EtOAc and successively washed with water and brine, dried over MgSO4, filtered and evaporated to give methyl 4-chloro-2-methoxybenzoate as a white solid (5.17 g, 96%).

来源