反应 #955

反应方程式

4-hydroxyethyl piperidine

N-benzyloxycarbonyl-S-methyl isothiourea

→

title compound

收率 41.0%

1-Benzyloxycarbonylamidino-4-hydroxyethyl piperidine

收率 41.0%

溶剂

acetonitrile

反应条件

后处理

1. 1
   温度was refluxed overnight
2. 2
   其他Evaporation and flash chromatography on silica gel with ethyl acetate

实验过程

A mixture of 6.2 g (0.028 mol) of 4-hydroxyethyl piperidine and 3.6 g (0.028 mol) of N-benzyloxycarbonyl-S-methyl isothiourea in 50 ml of acetonitrile was refluxed overnight. Evaporation and flash chromatography on silica gel with ethyl acetate gave 3.5 g (41%) of the title compound.

来源