反应 #954579

反应方程式

water

magnesium

2-ethoxy-5-bromopyridine

chlorodimethylsilane

→

2-ethoxy-5-dimethylsilylpyridine

收率 43.0%

溶剂

THF

tetrahydrofuran

反应条件

后处理

1. 1
   其他a strongly exothermic reaction
2. 2
   温度by refluxing for two hours
3. 3
   萃取extracted repeatedly with n-hexane
4. 4
   洗涤The extracts are washed with water and saturated sodium chloride solution
5. 5
   其他dried
6. 6
   其他evaporated
7. 7
   workup.DISTILLATIONthe residue is distilled

实验过程

A mixture of 18.2 g (0.09 mol) of 2-ethoxy-5-bromopyridine (can be obtained from 2,5-dibromopyridine and sodium methanolate in DMSO), 11.4 g (0.12 mol) of chlorodimethylsilane and 50 ml of anhydrous tetrahydrofuran (THF) is added dropwise to 2.4 g (0.10 mol) of magnesium turnings in 10 ml of anhydrous THF, a strongly exothermic reaction occurring. The reaction is completed by refluxing for two hours. The mixture is then poured into water and extracted repeatedly with n-hexane, The extracts are washed with water and saturated sodium chloride solution, dried and evaporated, and the residue is distilled. 7 g (43%) of 2-ethoxy-5-dimethylsilylpyridine are obtained as a colorless oil of boiling point 7=140°-150° C.

来源