反应 #95223

反应方程式

5-amino-3-trichloromethyl-1,2,4-thiadiazole

2,4-dichlorobenzoyl chloride

→

pure product

收率 69.5%

5-(2,4-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

收率 69.5%

溶剂

xylene

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated in vacuo
2. 2
   萃取the resulting residue extracted with benzene
3. 3
   workup.ADDITIONAddition of hexane

实验过程

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 20.9 g (0.10 mole) 2,4-dichlorobenzoyl chloride was refluxed in 200 ml xylene for 20 hours. The reaction mixture was concentrated in vacuo and the resulting residue extracted with benzene. Addition of hexane resulted in precipitation of 13.6 g (69% yield) pure product; m.p. 136° C.

来源