反应 #94868

反应方程式

Alloxan hydrate

1-Methylpyrrole

hydrogen chloride

→

title product

收率 65.0%

5-Hydroxy-5-(1-methyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione

收率 65.0%

溶剂

ethanol

反应条件

后处理

1. 1
   温度the mixture warmed for 5 minutes on a steam bath
2. 2
   其他the reaction mixture was evaporated to dryness
3. 3
   其他the residue triturated with water

实验过程

Alloxan hydrate (3.2 g., 0.02 mole) was dissolved in 50 ml. of ethanol by warming. 1-Methylpyrrole (1.6 g., 0.02 mole) was added and the mixture warmed for 5 minutes on a steam bath, while perfusing with hydrogen chloride. After standing at room temperature for 0.5 hour, the reaction mixture was evaporated to dryness and the residue triturated with water to yield title product as a solid [2.9 g.; m/e 223; Rf 0.5 (1:1 ethyl acetate:hexane/5% acetic acid)].

来源