反应 #945

反应方程式

benzaldehyde

product

Ethyl 2-aminobutyrate hydrochloride

magnesium sulphate

triethylamine

→

desired product

收率 88.9%

Ethyl 2-benzylideneaminobutyrate

收率 88.9%

溶剂

dichloromethane

反应条件

后处理

1. 1
   过滤then filtered
2. 2
   浓缩The filtrate was concentrated
3. 3
   其他triturated in diethyl ether
4. 4
   过滤filtered
5. 5
   浓缩concentrated

实验过程

A solution of the product from step (a) (149.6 g), magnesium sulphate (74.3 g), and triethylamine (246 ml) in dichloromethane (1500 ml) was stirred at room temperature under nitrogen and benzaldehyde (94.9 g, Aldrich) was added dropwise. The mixture was stirred at room temperature for 3 hours then filtered. The filtrate was concentrated, triturated in diethyl ether, filtered and concentrated to yield the desired product as a yellow oil (174 g). 1H NMR consistent with the proposed structure.

来源