反应 #943989

反应方程式

water

7-hydroxy-6-methoxy-1-tetralone

benzyl bromide

K2CO3

→

product

收率 62.8%

7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one

收率 62.8%

溶剂

acetone

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度to reflux overnight
3. 3
   其他The reaction
4. 4
   温度as cooled
5. 5
   萃取extracted with EtOAc
6. 6
   干燥The EtOAc was dried over Na2SO4
7. 7
   其他evaporated
8. 8
   其他to give 7 g of crude product
9. 9
   其他Crystallization with Et2O

实验过程

A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.

来源