反应 #943988

反应方程式

6,7-dimethoxy-1-tetralone

water

→

product

收率 81.3%

7-Hydroxy-6-methoxy-1-tetralone

收率 81.3%

溶剂

HOAc

HBr

反应条件

后处理

1. 1
   萃取extracted with EtOAc
2. 2
   干燥The EtOAc layer was dried
3. 3
   其他evaporated to 12 g of crude product
4. 4
   其他Purification on 1200 g of silica gel eluting with 10% Et2O in CH2Cl2

实验过程

A solution of 10 g (0.048 mole) of 6,7-dimethoxy-1-tetralone in 100 ml of HOAc and 100 ml of 48% aqueous HBr was heated at 95° C. for 7 hours. The reaction was cooled to room temperature and poured into water and extracted with EtOAc. The EtOAc layer was dried and evaporated to 12 g of crude product. Purification on 1200 g of silica gel eluting with 10% Et2O in CH2Cl2 gave 7.5 g of product. Mp 147-148° C. (literature mp 148-152° C., Journal of Organic Chemistry, 33, 1968, p. 508).

来源