反应 #93918

反应方程式

acetic acid

ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate

hydrogen peroxide

water

→

title compound

8-vinylsulfonyl-12-hydroxyheptadecanoic acid

溶剂

ether

反应条件

后处理

1. 1
   workup.ADDITIONThe solution is diluted with 600 ml
2. 2
   洗涤washed with dilute sodium bicarbonate solution and four portions of water
3. 3
   干燥dried over sodium sulfate
4. 4
   其他Evaporation of the ether in vacuo

实验过程

A solution of ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate (45.1 g., 0.1 mole) and 30% aqueous hydrogen peroxide (50 ml.) in acetic acid (225 ml.) is allowed to stand 20 hours at 25° C. The solution is diluted with 600 ml. of water. The oily product is taken up in ether, washed with dilute sodium bicarbonate solution and four portions of water and dried over sodium sulfate. Evaporation of the ether in vacuo leaves the title compound as a light yellow viscous oil.

来源