反应 #93882

反应方程式

N-benzhydryloxycarbonylglycine

pentachlorophenol

dicyclohexylcarbodiimide

→

N-benzhydryloxycarbonylglycine pentachlorophenyl ester

溶剂

ethyl acetate

反应条件

后处理

1. 1
   过滤filtered
2. 2
   其他The filtrate is evaporated
3. 3
   其他the residue is triturated with petroleum ether

实验过程

To a mixture consisting of 10 g. of N-benzhydryloxycarbonylglycine [this compound is reported in J. Am. Chem. Soc., 87, 3969 (1965)], 9.4 g. of pentachlorophenol, and 150 ml. of ethyl acetate, at 5° C., is added 7.3 g. of dicyclohexylcarbodiimide, and the resulting solution is kept at 5° C. for 5 hours and filtered. The filtrate is evaporated, and the residue is triturated with petroleum ether to give a solid precipitate of N-benzhydryloxycarbonylglycine pentachlorophenyl ester, which is isolated and dried; m.p. 171°-172° C.

来源