反应 #93769

反应方程式

Trichloroacetyl isocyanate

ethyl 6,9-dihydro-4,6-dioxo-8-methoxycarbonyl-10-propyl-4H-pyrano[3,2-g]quinoline-2-carboxylate

→

sub-title compound

Ethyl 8-methoxycarbonyl-4-oxo-10-propyl-6-trichloroacetamido-4H-pyrano[3,2-g)quinoline-2-carboxylate

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他the solvent removed by distillation in vacuo

实验过程

Trichloroacetyl isocyanate (1.18 ml, 10 mmol) was added to a solution of ethyl 6,9-dihydro-4,6-dioxo-8-methoxycarbonyl-10-propyl-4H-pyrano[3,2-g]quinoline-2-carboxylate (3.85 g, 10 mmol) in dichloromethane (20 ml) at room temperature. The solution was then agitated gently for 24 hours at room temperature and then the solvent removed by distillation in vacuo. Trituration of the resulting solid with ether gave the sub-title compound as yellow cubes, 4.25 g (80%), mp 167°-169° C.

来源